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Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers
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SYSNO ASEP 0331382 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers Title Biomarkery oxidace nukleových kyselin, polymorfismy a exprese pro hOGG1 gen u lidí exponovaných styrenu Author(s) Manini, P. (IT)
De Palma, G. (IT)
Andreoli, R. (IT)
Marczynski, B. (DE)
Hánová, Monika (UEM-P)
Mozzoni, P. (IT)
Naccarati, Alessio (UEM-P)
Vodičková, Ludmila (UEM-P) RID
Hlaváč, P. (CZ)
Mutti, A. (IT)
Vodička, Pavel (UEM-P) RIDSource Title Toxicology Letters. - : Elsevier - ISSN 0378-4274
Roč. 190, č. 1 (2009), s. 41-47Number of pages 7 s. Language eng - English Country IE - Ireland Keywords styrene exposure ; hOGG1 Ser326Cys polymorphism ; hOGG1 gene expression Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA500390806 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000269812300006 DOI 10.1016/j.toxlet.2009.06.862 Annotation This study investigated nucleic acid oxidation associated with styrene exposure, mRNA expression levels of hOGG1 gene and the role of the genetic polymorphism Ser326Cys of human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) in 60 styrene-exposed workers and 50 unexposed clerks. Styrene exposure seems to be associated with oxidation damage to nucleic acids, particularly to RNA and with an induction of the BER system. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
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