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Biomarkers of exposure to tobacco smoke and environmental pollutants in mothers and its transplacental transfer to the foetus. Part II: Oxidative damage
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SYSNO ASEP 0330450 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Biomarkers of exposure to tobacco smoke and environmental pollutants in mothers and its transplacental transfer to the foetus. Part II: Oxidative damage Title Biomarkery expozice tabákovému kouři and látkám znečišťujícím životní prostředí u matek a přenosu těchto látek přes placentu. Část II. Oxidační poškození Author(s) Rössner ml., Pavel (UEM-P) RID, ORCID
Milcová, Alena (UEM-P)
Líbalová, Helena (UEM-P) RID
Nováková, Zuzana (UEM-P)
Topinka, Jan (UEM-P) RID, ORCID
Balaščak, I. (CZ)
Šrám, Radim (UEM-P) RIDSource Title Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. - : Elsevier - ISSN 0027-5107
Roč. 669, 1-2 (2009), s. 20-26Number of pages 7 s. Language eng - English Country NL - Netherlands Keywords air pollution ; oxidative stress ; newborns Subject RIV DN - Health Impact of the Environment Quality R&D Projects 2B06088 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000271065800004 DOI 10.1016/j.mrfmmm.2009.04.010 Annotation Oxidative damage to DNA, lipids and proteins was measured in 80 newborns and 79 mothers. There was no difference in oxidation of either marker in newborns born to mothers exposed and unexposed to tobacco smoke. Protein oxidation was comparable in the umbilical cord and in maternal blood plasma. Lipid peroxidation was higher in newborns than in mothers. Protein oxidation and lipid peroxidation in cord blood correlated with those in maternal plasma. DNA oxidation in newborns was correlated was bulky DNA adducts in lymphocyte DNA of newborns and mothers. The results underlined close correlation of oxidative stress markers between newborns and mothers and a relationship between oxidative stress and induction of DNA adducts. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
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