Tetrathiafulvalene-labelled nucleosides and nucleoside triphosphates. Synthesis, electrochemistry and scope of their polymerase incorporation into DNA

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SYSNO ASEP	0328740
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Tetrathiafulvalene-labelled nucleosides and nucleoside triphosphates. Synthesis, electrochemistry and scope of their polymerase incorporation into DNA
Author(s)	Riedl, Jan (UOCHB-X) Horáková Brázdilová, Petra (BFU-R) Šebest, Peter (BFU-R)_ORCID Pohl, Radek (UOCHB-X)_{RID, ORCID} Havran, Luděk (BFU-R)_{RID, ORCID} Fojta, Miroslav (BFU-R)_{RID, ORCID} Hocek, Michal (UOCHB-X)_{RID, ORCID}
Number of authors	7
Source Title	European Journal of Organic Chemistry - ISSN 1434-193X -, č. 21 (2009), s. 3519-3525
Number of pages	7 s.
Language	eng - English
Country	DE - Germany
Keywords	nucleoside triphosphates ; DNA polymerase ; tetrathiafulvalene
Subject RIV	CC - Organic Chemistry
R&D Projects	IAA400040901 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
	AV0Z50040507 - BFU-R (2005-2011)
UT WOS	000268560700005
DOI	10.1002/ejoc.200900392
Annotation	DNA labeling by tetrathiafulvalene was attempted. TTF-modified nucleoside triphosphates were prepared and tested as substrates for DNA polymerases. Their enzymatic incorporation was inefficient and at higher concentration they fully inhibited the polymerase.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
Year of Publishing	2010

Number of the records: 1