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DNA interactions of antitumor doxorubicin and its more potent analog 2 pyrrolinodoxorubicin
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SYSNO ASEP 0328521 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title DNA interactions of antitumor doxorubicin and its more potent analog 2 pyrrolinodoxorubicin Title studium interakce protinádorového léčiva doxorubicinu a jeho analogu 2-pyrrolinodoxorubicinem s DNA Author(s) Štěpánková, Jana (BFU-R)
Vrána, Oldřich (BFU-R) RID
Studenovský, Martin (UMCH-V) RID, ORCID
Brabec, Viktor (BFU-R) RID, ORCIDSource Title Abstract. - Genoa, 2009 - ISSN 0175-7571
S66Number of pages 1 s. Action 7th EBSA, European Biophysics Congress Genoa Event date 11.07.2009-15.07.2009 VEvent location Genoa Country IT - Italy Event type EUR Language eng - English Country IT - Italy Keywords doxorubicin ; 2-pyrrolinodoxorubicin ; DNA Subject RIV BO - Biophysics R&D Projects GD301/09/H004 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) AV0Z40500505 - UMCH-V (2005-2011) Annotation The results of the mechanistic study confirm that p-DOX is an efficient DNA intercalator and that it can readily form covalent DNA adducts (interstrand crosslinks) independently of pH and in absence of formaldehyde. We suggest that these features of DNA binding mode of p-DOX are responsible for a dramatic enhancement of its toxicity in tumor cell lines in comparison with conventional DOX observed earlier. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2010
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