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Influence of DNA superhelicity on mutant p53 interactions with intronic and intrergenic sequences
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SYSNO ASEP 0328321 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title Influence of DNA superhelicity on mutant p53 interactions with intronic and intrergenic sequences Title Vliv DNA superhelicity na mutantní p53 interakce s intronovými a intergenovými sekvencemi Author(s) Navrátilová, Lucie (BFU-R)
Tichý, Vlastimil (BFU-R) RID
Němcová, Kateřina (BFU-R)
Kyjovský, Ivo (BFU-R)
Paleček, Emil (BFU-R) RID, ORCID
Fojta, Miroslav (BFU-R) RID, ORCID
Brázdová, Marie (BFU-R) RID, ORCIDSource Title Sborník příspěvků. - Brno, 2009 - ISBN 978-80-210-4830-0
S. 84Number of pages 1 s. Action Pracovní setkání biochemiků a molekulárních biologů /13./ Event date 14.04.2009-15.04.2009 VEvent location Brno Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords mutant p53 ; supercoiled DNA ; supercoiled-selective binding Subject RIV BO - Biophysics R&D Projects 1K04119 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LC06035 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) IAA500040701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA204/08/1560 GA ČR - Czech Science Foundation (CSF) GP204/06/P369 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) Annotation The majority of the hot spot full length mutant p53 proteins (mutp53fl) bind preferentially to supercoiled DNA. Competition experiments with linear DNA and supercoiled DNA uncovered supercoiled-selective binding of the mutp53fl. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2010
Number of the records: 1