Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly(ethylene oxide)

Matějíček, P.; Zedník, J.; Ušelová, K.; Pleštil, Josef; Fanfrlík, Jindřich; Nykanen, A.; Ruokolainen, J.; Hobza, Pavel; Procházka, K.

doi:https://dx.doi.org/10.1021/ma900484y

Number of the records: 1

Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly(ethylene oxide)

1.

SYSNO ASEP	0327533
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly(ethylene oxide)
Author(s)	Matějíček, P. (CZ) Zedník, J. (CZ) Ušelová, K. (CZ) Pleštil, Josef (UMCH-V)_RID Fanfrlík, Jindřich (UOCHB-X)_{RID, ORCID} Nykanen, A. (FI) Ruokolainen, J. (FI) Hobza, Pavel (UOCHB-X)_{RID, ORCID} Procházka, K. (CZ)
Source Title	Macromolecules. - : American Chemical Society - ISSN 0024-9297 Roč. 42, č. 13 (2009), s. 4829-4837
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	block-copolymer micelles ; light-scattering ; dicarbollide anions
Subject RIV	CD - Macromolecular Chemistry
R&D Projects	GD203/05/H001 GA ČR - Czech Science Foundation (CSF)
	1ET400500402 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	IAAX00320901 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000268138500068
DOI	10.1021/ma900484y
Annotation	The antiviral active boron cluster [3-cobalt bis(1,2-dicarbollide)](-1) anion, CoD, interacts and forms a stable complex with one of the most widely used polymeric component of drug delivery systems: poly(ethylene oxide), PEO. The formation of insoluble NaCoD/PEO complex can be exploited in design of water-soluble metallacarborane-containing nanoparticles that could offer applications in medicine. We studied the boron cluster interaction with a hydrophilic block copolymer: poly(ethylene oxide)-block-poly(methacrylic acid), PEO-PMA. The interaction leads to a spontaneous formation of core-shell nanoparticles. The insoluble core contains the PEO/CoD complex, while the polyanionic PMA blocks, which do not interact with the metallacarborane, form the pH-responsive micellar shell and stabilize the particles in aqueous media.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2010

Number of the records: 1