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Extremely high MHC class I variation in a population of a long-distance migrant, the Scarlet Rosefinch (Carpodacus erythrinus)
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SYSNO ASEP 0325113 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Extremely high MHC class I variation in a population of a long-distance migrant, the Scarlet Rosefinch (Carpodacus erythrinus) Author(s) Promerová, Marta (UBO-W)
Albrecht, Tomáš (UBO-W) RID, SAI, ORCID
Bryja, Josef (UBO-W) RID, SAI, ORCIDSource Title Immunogenetics. - : Springer - ISSN 0093-7711
Roč. 61, č. 6 (2009), s. 451-461Number of pages 11 s. Language eng - English Country DE - Germany Keywords MHC class I ; scarlet rosefinch ; positive selection ; recombination Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA600930608 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA206/06/0851 GA ČR - Czech Science Foundation (CSF) LC06073 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z60930519 - UBO-W (2005-2011) UT WOS 000266822700004 EID SCOPUS 67349255313 DOI 10.1007/s00251-009-0375-x Annotation We describe the structure and diversity of exon 3 of MHC class I in the Scarlet Rosefinch (Carpodacus erythrinus). Using SSCP, we identified 82 different variants in a population in the Czech Republic. This is the highest MHC class I variation observed in birds. We have not found support for "minimal essential" MHC in this species since individuals exhibited between 3 to 9 different exon 3 sequences, indicating that there may be at least 5 amplified class I genes. By cloning, we obtained and analysed 29 exon sequences and found that all of them could be translated into potentially functional proteins. We found that strong positive selection is acting mainly, but not only, on previously described antigen binding sites. Also, our results indicate that recombination has played an important role in generating diversity of these genes in the Scarlet Rosefinch; we discuss the significance of this genetic diversity in light of the life history traits of this species. Workplace Institute of Vertebrate Biology Contact Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Year of Publishing 2010
Number of the records: 1