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Identification of the first toll-like receptor gene in passerine birds: TLR4 orthologue in zebra finch (Taeniopygia guttata)
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SYSNO ASEP 0325112 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Identification of the first toll-like receptor gene in passerine birds: TLR4 orthologue in zebra finch (Taeniopygia guttata) Title Identifikace prvního Toll-like receptoru u pěvce: TLR4 ortolog u zebřičky (Taeniopygia guttata) Author(s) Vinkler, Michal (UBO-W) RID, ORCID
Bryjová, Anna (UBO-W) SAI, ORCID
Albrecht, Tomáš (UBO-W) RID, SAI, ORCID
Bryja, Josef (UBO-W) RID, SAI, ORCIDSource Title Tissue Antigens - ISSN 0001-2815
Roč. 74, č. 1 (2009), s. 32-41Number of pages 10 s. Language eng - English Country DK - Denmark Keywords avian immunogenetics ; comparative immunology ; evolutionary immunology Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA600930608 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC06073 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z60930519 - UBO-W (2005-2011) UT WOS 000266876500005 EID SCOPUS 66949152875 DOI 10.1111/j.1399-0039.2009.01273.x Annotation Toll-like receptors (TLRs) are the basic components of the vertebrate pathogen recognition system. Despite uniform general structure, remarkable variability in domain composition can be found in individual TLRs among species. Knowledge of interspecific differences is of particular importance to our understanding of selective pressures on TLRs. Currently, most TLRs are characterized only in a limited number of model species, including domestic chicken as a universal avian model. Here, we describe structure and expression pattern of TLR4 in zebra finch, a widely used passerine model species. The tgTlr4 gene consists of three exons (204, 167 and 3033–3043 bp) that are transcribed into messenger RNA. Predicted protein is composed of 842 amino acids. The gene is highly expressed in the bone marrow and in the spleen. For the first time in birds, expression of tgTLR4 in peritoneal macrophages was found to be enhanced by the Escherichia coli lipopolysaccharide treatment. Workplace Institute of Vertebrate Biology Contact Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Year of Publishing 2010
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