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Interferon-alpha treatment may negatively influence disease progression in melanoma patients by hyperactivation of STAT3 protein
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SYSNO ASEP 0324857 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Interferon-alpha treatment may negatively influence disease progression in melanoma patients by hyperactivation of STAT3 protein Title Léčba interferonem alfa může negativně ovlivnit průběh onemocnění maligním melanonem prostřednictvím hyperaktivovaného STAT3 proteinu Author(s) Humpolíková Adámková, L. (CZ)
Kovařík, J. (CZ)
Dušek, L. (CZ)
Lauerová, L. (CZ)
Boudný, V. (CZ)
Fait, V. (CZ)
Fojtová, Miloslava (BFU-R) RID, ORCID
Krejčí, E. (CZ)
Kovařík, Aleš (BFU-R) RID, ORCIDSource Title European Journal of Cancer. - : Elsevier - ISSN 0959-8049
Roč. 45, - (2009), s. 1315-1323Number of pages 9 s. Language eng - English Country NL - Netherlands Keywords malignant melanoma ; interferons ; STAT3 activation Subject RIV BO - Biophysics CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) DOI 10.1016/j.ejca.2009.01.009 Annotation In this work we have analysed phosphorylation and activation status of the STAT3 signal transduction molecule in primary melanoma cells. It is reported that the interferon alpha stimulated STAT3 phosphorylation in cells derived from patients with less favourable disease outcome but not in patients with relatively long survival interval. It is proposed that the adjuvant immunotherapy with interferon alpha could lead to activation of proliferative signals in some cases at least. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2009
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