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Synthesis of C3, C5, and C7 pregnane derivatives and their effect on NMDA receptor responses in cultured rat hippocampal neurons
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SYSNO ASEP 0323768 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis of C3, C5, and C7 pregnane derivatives and their effect on NMDA receptor responses in cultured rat hippocampal neurons Title Syntéza C3, C5 a C7 pregnanových derivátů a jejich vliv na NMDA receptory v kultuře krysích hipokampálních neuronů Author(s) Šťastná, Eva (UOCHB-X) ORCID
Chodounská, Hana (UOCHB-X) RID, ORCID
Pouzar, Vladimír (UOCHB-X)
Kapras, Vojtěch (UOCHB-X)
Borovská, Jiřina (UOCHB-X)
Cais, Ondřej (FGU-C)
Vyklický ml., Ladislav (FGU-C) RID, ORCID, SAINumber of authors 7 Source Title Steroids. - : Elsevier - ISSN 0039-128X
Roč. 74, č. 2 (2009), s. 256-263Number of pages 8 s. Language eng - English Country US - United States Keywords pregnane derivatives ; NMDA receptor ; structure-activity relationship ; patch-clamp recording Subject RIV CC - Organic Chemistry R&D Projects GA309/07/0271 GA ČR - Czech Science Foundation (CSF) GA203/08/1498 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) AV0Z50110509 - FGU-C (2005-2011) UT WOS 000263621400013 DOI 10.1016/j.steroids.2008.11.011 Annotation The synthesis of several novel 5alpha- and 5beta-20-oxo-pregnane derivatives substituted in the position 3 and 7 of the steroid skeleton is described. Activity of synthesized compounds was studied in voltage-clamped cultured rat hippocampal neurons. Substituted derivatives inhibited NMDA-elicited neuronal activity. The relationship between biological activity and structure is discussed. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2009
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