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Nitroxide radical TEMPO reduces ozone-induced chemokine IL-8 production in lung epithelial cells
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SYSNO ASEP 0323281 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Nitroxide radical TEMPO reduces ozone-induced chemokine IL-8 production in lung epithelial cells Title Nitrooxidový radikál TEMPO snižuje produkci chemokinu IL-8 po působení ozónu v plicních epiteliálních buňkách Author(s) Castagna, R. (IT)
Davis, P.A. (US)
Vasu, V.T. (US)
Souček, Karel (BFU-R) RID, ORCID
Cross, C.E. (US)
Greci, L. (IT)
Valacchi, G. (IT)Source Title Toxicology in Vitro. - : Elsevier - ISSN 0887-2333
Roč. 23, č. 3 (2009), s. 365-370Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords interleukin-8 ; ozone ; lung epithelial cells Subject RIV BO - Biophysics CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000264510200001 DOI 10.1016/j.tiv.2008.12.016 Annotation Exposure to high levels of ozone damages respiratory tract epithelial cells. This research evaluated the ability of TEMPO, a stable nitroxide free radical, to decrease ozone-mediated injury to a respiratory tract-derived cell line (A549 cells) by monitoring in this cell system the interleukine-8 (IL-8) production. TEMPO reduced ozone-induced IL-8 production in A549 cells. The study provides evidence that TEMPO reacts with O(3) and/or its cytotoxic products and may provide protections against O(3)-induced biotoxicities. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2009
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