Alternative Muscle Club. - Leeds : University of Leeds, 2008
S. 36-36
Number of pages
1 s.
Action
Alternative Muscle Club /26th/
Event date
23.07.2008-25.07.2008
VEvent location
Leeds
Country
GB - United Kingdom
Event type
WRD
Language
eng - English
Country
GB - United Kingdom
Keywords
nuclear mysion
Subject RIV
EB - Genetics ; Molecular Biology
R&D Projects
GA204/07/1592 GA ČR - Czech Science Foundation (CSF)
LC545 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ
AV0Z50520514 - UMG-J (2005-2011)
Annotation
The research is focused on the function of a nuclear isoform of myosin molecular motor - nuclear myosin I (NM1). This nuclear motor was shown to be involved in transcription, chromatin remodelling and repositioning of transcriptionaly activated regions in the nucleoplasm. NM1 differs from its cytoplasmic variant myosin IC by a unique N-terminal extension of unknown function. We are interested in the structure of the motor domain of NM1 and the relation to the N-terminal domain as it could elucidate the specific properties of the molecule that allow it to perform its nuclear roles.
