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The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo
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SYSNO ASEP 0321312 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo Title Extracelulární část proteinu Lrp5/6 inhibuje nekanonickou Wnt dráhu in vivo Author(s) Bryja, Vítězslav (BFU-R) RID, ORCID
Andersson, E.R. (SE)
Schambony, A. (DE)
Esner, M. (FR)
Bryjová, Lenka (BFU-R)
Biris, K.K. (US)
Hall, A.C. (SE)
Kraft, B. (DE)
Čajánek, L. (DE)
Yamaguchi, T.P. (US)
Buckingham, M. (FR)
Arenas, E. (SE)Source Title Molecular Biology of the Cell - ISSN 1059-1524
Roč. 20, č. 3 (2009), s. 924-936Number of pages 13 s. Language eng - English Country US - United States Keywords non-canonical Wnt signaling ; Lrp5/6 ; mouse Subject RIV BO - Biophysics CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000263031900017 DOI 10.1091/mbc.E08-07-0711 Annotation Lrp5/6 are crucial coreceptors for Wnt/beta-catenin signaling, a pathway biochemically distinct from noncanonical Wnt signaling pathways. Here we examined the possible participation of Lrp5/6 in noncanonical Wnt signaling using biochemical approach, and mouse and xenopus in vivo models. We provide evidence that the extracellular domains of Lrp5/6 behave as physiologically relevant inhibitors of noncanonical Wnt signaling during xenopus and mouse development in vivo. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2009
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