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DNA interactions of dinuclear RuII arene antitumor complexes in cell-free media
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SYSNO ASEP 0320869 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title DNA interactions of dinuclear RuII arene antitumor complexes in cell-free media Title Interakce DNA s protinádorově aktivními dinukleárními RuII komplexy in vitro Author(s) Nováková, Olga (BFU-R) RID, ORCID
Nazarov, A.A. (AT)
Hartinger, Ch.G. (AT)
Keppler, B.K. (AT)
Brabec, Viktor (BFU-R) RID, ORCIDSource Title Biochemical Pharmacology. - : Elsevier - ISSN 0006-2952
Roč. 77, č. 3 (2009), s. 364-374Number of pages 11 s. Language eng - English Country US - United States Keywords dinuclear ruthenium complex ; DNA ; cross-links Subject RIV BO - Biophysics R&D Projects LC06030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ME08017 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) OC08003 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1QS500040581 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000262935900007 DOI 10.1016/j.bcp.2008.10.021 Annotation DNA modifications by new dinuclear RuII arene compounds were studied. The complexes bind DNA forming intrastrand and interstrand cross-links in one DNA molecule. An intriguing aspect of the DNA-binding mode of these dinuclear RuII compounds is that they can crosslink two DNA duplexes and also proteins to DNA. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2009
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