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Arachidonic Acid Derivatives in the Exhaled Breath Condensate in Pneumoconioses and their Correlation with Individual Factors
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SYSNO ASEP 0319397 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Arachidonic Acid Derivatives in the Exhaled Breath Condensate in Pneumoconioses and their Correlation with Individual Factors Title Deriváty kyseliny arachidonové v kondenzátu vydechovaného vzduchu u Pneumokonióz a korelace s jednotlivými faktory Author(s) Pelclová, D. (CZ)
Fenclová, Z. (CZ)
Kačer, J. (CZ)
Navrátil, Tomáš (UFCH-W) RID, ORCID
Kuzma, Marek (MBU-M) ORCID, RID
Lebedová, J. (CZ)
Klusáčková, P. (CZ)Source Title Chemické listy. - : Česká společnost chemická - ISSN 0009-2770
Roč. 101, s (2007), s144-s146Number of pages 3 s. Action Mezioborová česko-slovenská toxikologická konference /12./ Event date 11.06.2007-13.06.2007 VEvent location Praha Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords silica ; asbestos ; leukotrienes Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects NR9338 GA MZd - Ministry of Health (MZ) CEZ AV0Z40400503 - UFCH-W (2005-2011) AV0Z50200510 - MBU-M (2005-2011) Annotation This study confirms that exhaled breath condensate analysis of leukotriens (LTs) is useful in fibrogenic dust exposed subjects, especially LTD4 and LTE4. LT D4 was higher both in the subjects with asbestos exposure and in the silicotics and might point to the activity of the fibrogenic process; on the other hand LT E4 correlated with the level of exposure - asbestos fiber-years and category of silica exposure. On the other hand, LT C4 correlated with chronic obstructive pulmonary disease. No correlation with daily alcohol consumption, cigarettes/day or systemic diseases was found for LTD4 and LTE4, which supports the theory that analysis of exhaled breath condensate reflects solely processes ongoing in the lungs. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2009
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