Detection of Borrelia bissettii in cardiac valve tissue of a patient with endocarditis and aortic valve stenosis in the Czech Republic

Rudenko, Natalia; Golovchenko, Maryna; Mokráček, A.; Piskunova, N.; Růžek, Daniel; Mallátová, N.; Grubhoffer, Libor

doi:https://dx.doi.org/10.1128/JCM.01032-08

Number of the records: 1

Detection of Borrelia bissettii in cardiac valve tissue of a patient with endocarditis and aortic valve stenosis in the Czech Republic

1.

SYSNO ASEP	0318391
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Detection of Borrelia bissettii in cardiac valve tissue of a patient with endocarditis and aortic valve stenosis in the Czech Republic
Title	Detekce Borrelia bissettii v tkáni srdeční chlopně u pacienta s endokarditidou a stenózou aortální chlopně v České republice
Author(s)	Rudenko, Natalia (BC-A)_{RID, ORCID} Golovchenko, Maryna (BC-A)_{RID, ORCID} Mokráček, A. (CZ) Piskunova, N. (CZ) Růžek, Daniel (BC-A)_{RID, ORCID} Mallátová, N. (CZ) Grubhoffer, Libor (BC-A)_{RID, ORCID}
Number of authors	7
Source Title	Journal of Clinical Microbiology - ISSN 0095-1137 Roč. 46, č. 10 (2008), s. 3540-3543
Number of pages	4 s.
Language	eng - English
Country	US - United States
Keywords	Lyme disease ; Borrelia bissettii ; carditis ; causative agent
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	LC06009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GD524/03/H133 GA ČR - Czech Science Foundation (CSF)
	GA524/06/1479 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z60220518 - PAU-O, BC-A (2005-2011)
UT WOS	000259758900064
DOI	10.1128/JCM.01032-08
Annotation	Lyme disease is well known for affecting the myocardium in the form of carditis. Spirochetes are one group of bacteria with a predilection for cardiac infection. We presented here a case of third-degree AV block in a patient with Lyme disease in anamnesis, with negative results from bacterial cultivation but confirmation by molecular techniques of the presence of B. bissettii DNA in the valve tissue. Our case provides evidence that DNA from the causative agent of Lyme disease may persist in the cardiac valves of patients some time after the infection is cured by a course of antibiotics. Moreover, the presence of B. bissettii as the single Borrelia strain in patients with symptomatic borreliosis or chronic borrelial infections strongly supports the fact that B. bissettii may indeed be a causative agent of Lyme disease.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2009

Number of the records: 1