Target site preference of subgroup C Rous sarcoma virus integration into the chicken DNA

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SYSNO ASEP	0318320
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	Target site preference of subgroup C Rous sarcoma virus integration into the chicken DNA
Title	Integrační preference viru Rousova sarkomu podskupiny C do kuřecí DNA
Author(s)	Reinišová, Markéta (UMG-J) Pavlíček, Adam (UMG-J) Divina, Petr (UMG-J) Geryk, Josef (UMG-J)_RID Plachý, Jiří (UMG-J)_RID Hejnar, Jiří (UMG-J)_RID
Source Title	Open Genomics Journal - ISSN 1875-693X Roč. 1, - (2008), s. 6-12
Number of pages	7 s.
Language	eng - English
Country	US - United States
Keywords	retroviral integration ; integration preference ; RSV
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	GA204/07/1030 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50520514 - UMG-J (2005-2011)
Annotation	We sequenced unselected integration sites of subgroup C RSV from infected chicken cells and mapped them on the chicken draft genome assembly. RSV-C integrates non-randomly into genes, gene-rich regions, and GC-rich regions. RSV-C does not display any preference for neither transcription starts nor microchromosomes, which might be very important for the development of gene ransfer vectors and gene therapy strategies.
Workplace	Institute of Molecular Genetics
Contact	Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
Year of Publishing	2009

Number of the records: 1