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Chronic intermittent hypoxia stimulates 11HSD2 in rat heart myocardium
- 1.0318281 - FGÚ 2009 DE eng A - Abstract
Řeháková, Lenka - Klusoňová, Petra - Kolář, František - Borchert, Gudrun H. - Neckář, Jan - Pácha, Jiří
Chronic intermittent hypoxia stimulates 11HSD2 in rat heart myocardium.
[Chronická intermitentní hypoxie stimuluje 11HSD2 v myokardu potkana.]
Workshop on Pre-receptor steroid metabolism as target for pharmacological treatment. Neuherberg: German Research Center for Environmental Health, 2008. P23-P23.
[Workshop on Pre-receptor steroid metabolism as target for pharmacological treatment. 26.05.2008-28.05.2008, Neuherberg]
R&D Projects: GA ČR(CZ) GA305/07/0328; GA ČR(CZ) GA305/07/0875
Institutional research plan: CEZ:AV0Z50110509
Keywords : spo2 * corticosteroids * hypoxia
Subject RIV: ED - Physiology
Glucocorticoids and mineralocorticoids modulate cardiovascular homeostasis. Rats exposed to chronic intermittent hypoxia increase marker of inflammation osteopontin, the oxidation of corticosterone to 11-dehydrocorticosterone and the level of 11HSD2 mRNA in both the myocardium and the isolated cardiomyocytes. The expression of glucocorticoid and mineralocorticoid receptors was not changed
Glukokortikoidy a mineralokortikoidy modulují kardiovaskulární homeostázu. U potkanů vystavených chronické intermitentní hypoxii se zvyšuje marker zánětu osteopontin, oxidace kortikosteronu na 11-dehydrokortikosteron a hladina 11HSD2 mRNA v myokardu i izolovaných kardiomyocytech. Exprese glukokortikoidních a mineralokortikoidních receptorů nebyla změněna
Permanent Link: http://hdl.handle.net/11104/0167739
Number of the records: 1