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Mitochondrial fatty acid synthesis is required for normal mitochondrial morphology and function in Trypanosoma brucei
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SYSNO ASEP 0318140 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mitochondrial fatty acid synthesis is required for normal mitochondrial morphology and function in Trypanosoma brucei Title Syntéza mastných kyselin je nezbytná pro zachování mitochondriální morfologie a funkce u Trypanosoma brucei Author(s) Guler, J. L. (US)
Kriegová, Eva (BC-A) SAI
Smith, T. K. (GB)
Lukeš, Julius (BC-A) RID, ORCID
Englund, P. T. (US)Number of authors 5 Source Title Molecular Microbiology - ISSN 0950-382X
Roč. 67, č. 5 (2008), s. 1125-1142Number of pages 18 s. Language eng - English Country GB - United Kingdom Keywords Trypanosoma ; mitochondrion ; fatty acid ; RNA interference Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA204/06/1558 GA ČR - Czech Science Foundation (CSF) LC07032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 2B06129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000252932000014 DOI 10.1111/j.1365-2958.2008.06112.x Annotation Trypanosoma brucei use microsomal elongases for de novo synthesis of most of its fatty acids. In addition, the parasite utilizes an essential mitochondrial type II synthase for production of octanoate as well as longer fatty acids such as palmitate. We have shown that the mitochondrial synthase produces fatty acids needed for maintaining local phospholipid levels that are required for activity of respiratory complexes and preservation of mitochondrial morphology and function. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2009
Number of the records: 1