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Mutations in p53, p53 protein overexpression and breast cancer survival
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SYSNO ASEP 0315848 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Mutations in p53, p53 protein overexpression and breast cancer survival Title Mutace v p53, overexprese proteinu p53 a přežití osob s rakovinou prsu Author(s) Rössner ml., Pavel (UEM-P) RID, ORCID
Gammon, M. D. (US)
Zhang, Y.J. (US)
Terry, M. B. (US)
Hibshoosh, H. (US)
Memeo, L. (IT)
Mansukhani, M. (US)
Long, CH.M. (US)
Gabrowski, G. (US)
Agrawal, M. (US)
Kalra, T.S. (US)
Teitelbaum, S. L. (US)
Neugut, A. I. (US)
Santella, R. M. (US)Source Title Journal of Cellular and Molecular Medicine. - : Wiley - ISSN 1582-1838
Roč. 13, č. 9B (2009), s. 3847-3857Number of pages 11 s. Language eng - English Country RO - Romania Keywords Breast cancer ; p53 mutations ; Survival Subject RIV DN - Health Impact of the Environment Quality CEZ AV0Z50390512 - UEM-P (2005-2011) DOI doi:10.1111/1.1582-4934.2008.00553.x Annotation The study analyzing mutations in p53, overexpression of p53 protein, their association with selected tumor clinical parametres and the association of p53 markers with survival amomg 859 women diagnosed with breast cancer. The prevalence of p53 overexpression in the tumor was 36% and of any p53 mutation was 15%. Overexpression of p53 was positively associated with the presence of any p53 mutation. Any p53 mutation and missense mutations were associated with breast cancer-specific and all-cause mortality. These associations however did not remain after adjusting for estrogen/progesterone receptor status. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2009
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