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Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: Involvement of inducible nitric oxide synthase and hemoxygenase-1
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SYSNO ASEP 0315839 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: Involvement of inducible nitric oxide synthase and hemoxygenase-1 Title Vliv resveratrolu na toxicitu tert-butylhydroperoxidu u imobilizovaných perfundovaných hepatocytů: Úloha inducibilní NO syntasy a hemoxygenasy-1 Author(s) Černý, D. (CZ)
Kutinová-Canová, N. (CZ)
Martínek, J. (CZ)
Hořínek, A. (CZ)
Kmoníčková, Eva (UEM-P) RID
Zídek, Zdeněk (UEM-P)
Farghali, H. (CZ)Source Title Nitric Oxide-Biology and Chemistry. - : Elsevier - ISSN 1089-8603
Roč. 20, č. 1 (2009), s. 1-8Number of pages 8 s. Language eng - English Country NL - Netherlands Keywords Resveratrol ; Hepatocyte ; Nitric oxide Subject RIV FR - Pharmacology ; Medidal Chemistry R&D Projects GA305/07/0061 GA ČR - Czech Science Foundation (CSF) 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000261231600001 DOI doi:10.1016/j.niox.2008.08.006 Annotation Resveratrol and silymarin reduce toxic effects induced in rat hepatocytes by tert-butylhydroperoxide. Their protective effects depend on suppression of the inducible nitric oxide synthase (NOS-2) and hemoxygenase-1 (HO-1) gene expression. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2009
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