Number of the records: 1
MMP19 is essential for T cell development and T cell-mediated cutaneous immune responses
- 1.
SYSNO ASEP 0311095 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title MMP19 is essential for T cell development and T cell-mediated cutaneous immune responses Title MMP19 je nezbytná pro vývoj T buněk a pro imunitní odpoveď kůže zprostředkovanou T buňkami Author(s) Beck, Inken (UMG-J) RID
Ruckert, R. (DE)
Brandt, K. (DE)
Mueller, M.S. (CH)
Sadowski, T. (DE)
Brauer, R. (DE)
Schirmacher, P. (DE)
Mentlein, R. (DE)
Sedláček, Radislav (UMG-J) RIDSource Title PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 3, č. 6 (2008), e2343-e2343Number of pages 11 s. Language eng - English Country US - United States Keywords matrix metalloproteinase ; T cell ; immune response Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50520514 - UMG-J (2005-2011) AV0Z50520701 - BTO-N (2007-2013) Annotation MMP19 affects cell proliferation, adhesion and migration but its physiological role is unclear. To determine the role of MMP19 in vivo we generated MMP19-deficient mice. In a contact hypersensitivity model these mice showed impaired T cell-mediated immune reaction characterized by limited influx of inflammatory cells, low proliferation of keratinocytes and reduced number of activated CD8+ T cells in draining lymph nodes. In the inflamed tissue the low number of CD8+ T cells in MMP19-deficient mice correlated with low amounts of proinflammatory cytokines (lymphotactin, I-TAC). T cell populations in the blood of immature, unsensitized mice were diminished due to an altered maturation of thymocytes. In the thymus thymocytes exhibited low proliferation rates and the number of CD4+CD8+ double-positive cells was strongly augmented. Based on the phenotype of MMP19-deficient mice we propose that MMP19 is an important factor in cutaneous immune responses and influences T cell development. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2009
Number of the records: 1