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The role of Pax genes in eye evolution
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SYSNO ASEP 0310875 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The role of Pax genes in eye evolution Title Role Pax genů v evoluci oka Author(s) Kozmik, Zbyněk (UMG-J) RID Source Title Brain Research Bulletin. - : Elsevier - ISSN 0361-9230
Roč. 75, 2-4 (2008), s. 335-339Number of pages 5 s. Language eng - English Country US - United States Keywords eye ; Pax ; evolution Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA500520604 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) 1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000255099000026 Annotation Anatomically widely different designs of animal eyes have long been thought to arise independently multiple times during evolution. This morphology-based view has been challenged by the identification of a highly conserved transcription factor Pax6 that plays a key role in eye development in both flies and mammals. The origin of Pax genes predates the origin of eyes and the nervous system since a PaxB-like gene, belonging to the Pax2/5/8 gene subfamily, was identified in sponge lacking nervous system. Structurally similar PaxB gene is implicated in visual system development in jellyfish, the most basal organism possessing complex eyes. The widespread use of Pax genes in the genetic program underlying eye formation throughout the animal kingdom raises a question why certain transcription factors have been frequently redeployed to build eyes. A model is proposed that provides a plausible explanation for the apparently ancient role of Pax genes in eye evolution. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2009
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