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Late blood pressure reduction in shr subjected to transient captopril treatment in youth: possible mechanisms
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SYSNO ASEP 0310364 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Late blood pressure reduction in shr subjected to transient captopril treatment in youth: possible mechanisms Title Pozdní snížení krevního tlaku u spontánně hypertenzních potkanů vystavených přechodnému podávání kaptoprilu v mládí: možné mechanismy Author(s) Zicha, Josef (FGU-C) RID, ORCID, SAI
Dobešová, Zdenka (FGU-C)
Kuneš, Jaroslav (FGU-C) RID, ORCIDSource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 57, č. 3 (2008), s. 495-498Number of pages 4 s. Language eng - English Country CZ - Czech Republic Keywords captopril ; nifedipine ; late effects of early treatment Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery R&D Projects 1M0510 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA305/08/0139 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000257270900024 Annotation Our study was aimed to elucidate the mechanisms responsible for long-term persistence of blood pressure reduction after early blockade of angiotensin II formation by captopril. It was found that blood pressure reduction was caused by attenuation of sympathetic vasoconstriction (sensitive to nifedipine) and by lowering of residual blood pressure (reflecting structural alterations of resistance vessels) Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2009
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