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Conformational transitions of flanking purines in HIV-1 RNA dimerization initiation site kissing complexes studied by charmm explicit solvent molecular dynamics

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    SYSNO ASEP0310357
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleConformational transitions of flanking purines in HIV-1 RNA dimerization initiation site kissing complexes studied by charmm explicit solvent molecular dynamics
    TitleKonformační přechody volných bází v rNA "kissing" komplexech viru HIV-1 studované molekulově dynamickými simulacemi v explicitním solventu pomocí Charmmu
    Author(s) Sarzynska, J. (PL)
    Réblová, Kamila (BFU-R)
    Šponer, Jiří (BFU-R) RID, ORCID
    Kulinski, T. (PL)
    Source TitleBiopolymers - ISSN 0006-3525
    Roč. 89, č. 9 (2008), s. 732-746
    Number of pages15 s.
    Languageeng - English
    CountryUS - United States
    Keywordsmolecular dynamics ; RNA ; force field
    Subject RIVBO - Biophysics
    R&D ProjectsLC06030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    1QS500040581 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
    CEZAV0Z50040507 - BFU-R (2005-2011)
    AV0Z50040702 - BFU-R (2007-2013)
    UT WOS000257822000003
    DOI https://doi.org/10.1002/bip.21001
    AnnotationStudy of flanking bases in RNA kissing loop complexes using Charmm force field shows good agreement with experiments carried out by Amber and with X-ray crystalography. The study describes multiple conformations, which flanking bases may adopt on nanosecond time scale.
    WorkplaceInstitute of Biophysics
    ContactJana Poláková, polakova@ibp.cz, Tel.: 541 517 244
    Year of Publishing2009
Number of the records: 1  

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