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Metalation of 6-halo-2,4-dimethoxypyrimidines as the key step for the synthesis of biologicaly active compounds
- 1.0309994 - ÚOCHB 2009 RIV CZ eng C - Conference Paper (international conference)
Nencka, Radim - Hřebabecký, Hubert - Votruba, Ivan - Dračínský, Martin - Holý, Antonín
Metalation of 6-halo-2,4-dimethoxypyrimidines as the key step for the synthesis of biologicaly active compounds.
[Metalace 6-halo-2,4-dimethoxypyrimidinů jako klíčový krok pro syntézu biologicky aktivních sloučenin.]
Chemistry of Nucleic Acid Components. Praha: Institute of Organic Chemistry and Biochemistry ASCR, 2008 - (Hocek, M.), s. 249-253. Collection Symposium Series, 10. ISBN 978-80-86241-29-6.
[Symposium on Chemistry of Nucleic Acid Components /14./. Český Krumlov (CZ), 08.06.2008-13.06.2008]
R&D Projects: GA MŠMT 1M0508; GA AV ČR 1QS400550501
Institutional research plan: CEZ:AV0Z40550506
Keywords : pyrimidine * organometallic * cross-coupling * lithiation
Subject RIV: CC - Organic Chemistry
Introduction of carbon substituents to the position C-5 and C-6 of uracil ring was performed by reaction of organometallic derivatives of uracil with electrophiles or by transition metal catalyzed cross-coupling reaction. Especially lithiathion was studied intensively.
Zavedení uhlíkatých substituentů do polohy C-5 a C-6 na uracilovém kruhu bylo provedeno reakcí organokovových derivátů uracilu s elektrofily nebo cross-couplingem. Hlavní pozornost byla věnována lithiacím.
Permanent Link: http://hdl.handle.net/11104/0161994
Number of the records: 1