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Direct C-H arylation of purines and purine nucleosides
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SYSNO ASEP 0309916 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Direct C-H arylation of purines and purine nucleosides Title Přímá C-H arylace purinů a purinových nukleosidů Author(s) Čerňa, Igor (UOCHB-X)
Hocek, Michal (UOCHB-X) RID, ORCIDSource Title Chemistry of Nucleic Acid Components. - Praha : Institute of Organic Chemistry and Biochemistry ASCR, 2008 / Hocek Michal - ISBN 978-80-86241-29-6 Pages s. 327-329 Number of pages 3 s. Action Symposium on Chemistry of Nucleic Acid Components /14./ Event date 08.06.2008-13.06.2008 VEvent location Český Krumlov Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords C-H activation ; nucleosides ; cross-coupling Subject RIV CC - Organic Chemistry R&D Projects GA203/05/0043 GA ČR - Czech Science Foundation (CSF) LC06077 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000257885700065 Annotation Direct C–H arylation of purines to position 8 by diverse aryl halides was achieved using Pd catalysis in the presence of CuI and Cs2CO3. The methodology was applied in consecutive regioselective synthesis of 2,6,8-trisubstituted purines bearing three different C-substituents in combination with two cross-coupling reaction. In addition, direct arylation of unprotected purine nucleosides with aryl iodides at position 8 was developed to allow straightforward single-step introduction of diverse aryl groups. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2009
Number of the records: 1