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Multiple defects in negative regulation of PKB/Akt pathway sensitize cancer cells to anti proliferative effect of non steroidal anti inflammatory drugs
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SYSNO ASEP 0309092 Document Type A - Abstract R&D Document Type Není vybrán druh dokumentu Title Multiple defects in negative regulation of PKB/Akt pathway sensitize cancer cells to anti proliferative effect of non steroidal anti inflammatory drugs Title Mnohočetné poruchy v negativní regulaci signální dráhy PKB/Akt zcitlivují lidské nádorové buňky k antiproliferačnímu účinku nesteroidních antiflogistik Author(s) Lincová, Eva (BFU-R)
Souček, Karel (BFU-R) RID, ORCID
Staršíchová, Andrea (BFU-R)
Pernicová, Zuzana (BFU-R) RID
Hampl, A. (CZ)
Kozubík, Alois (BFU-R) RID, ORCIDSource Title Chemické listy. - : Česká společnost chemická - ISSN 0009-2770
Roč. 102, č. 5 (2008), s. 384Number of pages 1 s. Action Mezioborové setkání mladých biologů, biochemiků a chemiků. Konference Sigma-Aldrich /8./ Event date 10.06.2008-13.06.2008 VEvent location Devět skal - Žďárské vrchy Country CZ - Czech Republic Event type CST Language eng - English Country CZ - Czech Republic Keywords PKB/Akt signaling pathway ; NSAIDs ; prostate cancer Subject RIV BO - Biophysics R&D Projects GA204/07/0834 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) Annotation The PKB/Akt signaling pathway, frequently hyperactivated in human cancer, is negative regulated by PTEN and SHIP2 phosphatases. Human cancer cell lines lacking both of these negative regulators are substantially more sensitive to antiproliferative effect of non-steroidal anti-inflammatory drugs. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2009
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