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CDC25A phosphatase controls meiosis I progression in mouse oocytes
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SYSNO ASEP 0307953 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title CDC25A phosphatase controls meiosis I progression in mouse oocytes Title CDC25A fosfatáza reguluje průchod meiózou I v myších oocytech Author(s) Šolc, Petr (UZFG-Y) RID, ORCID
Šašková, Adéla (UZFG-Y)
Baran, V. (SK)
Kubelka, Michal (UZFG-Y) RID, ORCID
Schultz, R. M. (US)
Motlík, Jan (UZFG-Y) RID, ORCIDSource Title Developmental Biology. - : Elsevier - ISSN 0012-1606
Roč. 317, č. 1 (2008), s. 260-269Number of pages 10 s. Language eng - English Country US - United States Keywords resumption of meiosis ; meiotic maturation ; mouse oocytes Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA305/06/1413 GA ČR - Czech Science Foundation (CSF) GD204/05/H023 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50450515 - UZFG-Y (2005-2011) Annotation This paper uses functional studies (RNAi, mRNA microinjection) to uncover a role of CDC25A in female meiosis. CDC25A cooperates together with CDC25B during resumption of meiosis, destruction of CDC25A in prometaphase I is crucial for MI-MII transition. CDC25A is exclusively localized to the nucleus prior to nuclear envelope breakdown (NEBD). In contrast, CDC25B localizes to cytoplasm in GV-intact oocytes and translocates to the nucleus shortly before NEBD. CDC25A behaves differently during female meiosis than during mitosis, and moreover, that CDC25A has a function in resumption of meiosis, MI spindle formation and the MI–MII transition. Thus, both CDC25A and CDC25B are critical for meiotic maturation of oocytes. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2008
Number of the records: 1