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Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid
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SYSNO ASEP 0307239 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid Title Antikonvulzivní a neuroprotekční účinek (S)-3,4-dikarboxyfenylglycinu za křečí vyvolaných u mláďat laboratorního potkana kyselinou homocysteovou Author(s) Folbergrová, Jaroslava (FGU-C) RID
Druga, Rastislav (FGU-C) RID, ORCID, SAI
Haugvicová, Renata (FGU-C)
Mareš, Pavel (FGU-C) RID, ORCID
Otáhal, Jakub (FGU-C) RID, ORCID, SAISource Title Neuropharmacology. - : Elsevier - ISSN 0028-3908
Roč. 54, č. 4 (2008), s. 665-675Number of pages 11 s. Language eng - English Country NL - Netherlands Keywords DL-homocysteic acid induced seizures ; mGluR8 agonist (S)-3,4-DCPG ; protection Subject RIV FH - Neurology R&D Projects GA309/02/1238 GA ČR - Czech Science Foundation (CSF) GA309/05/2015 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000254231300004 DOI 10.1016/j.neuropharm.2007.11.015 Annotation Pretreatment with a selective agonist for subype 8 of group III metabotropic glutamate receptors (S)-3,4-dicarboxyphenylglycine provided a marked anticonvulsant and neuroprotective effect against seizures induced in immature rats by homocysteic acid. Anticonvulsant effect was evaluated from the EEG recordings and energy metabolism changes, neuroprotective effect by means of 2 methods (Nissl and Fluoro-Jade B staining) Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2008
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