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Biodegradable high-molecular-weith polymer drug carriers based on HPMA copolymers
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SYSNO ASEP 0306675 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Biodegradable high-molecular-weith polymer drug carriers based on HPMA copolymers Title Biodegradovatelné vysokomolekulární polymerní nosiče léčiv na bázi HPMA kopolymerů Author(s) Chytil, Petr (UMCH-V) RID, ORCID
Etrych, Tomáš (UMCH-V) RID, ORCID
Ulbrich, Karel (UMCH-V) RIDSource Title Abstract Book - Tenth European Symposium on Controlled Drug Delivery. - Noordwijk aan Zee : University of Twente, 2008 / Sam A.P. - ISBN 978-90-365-2653-1 Pages s. 229-231 Number of pages 3 s. Action European Symposium on Controlled Drug Delivery /10./ Event date 02.04.2008-04.04.2008 VEvent location Noordwijk aan Zee Country NL - Netherlands Event type WRD Language eng - English Country NL - Netherlands Keywords HPMA copolymers ; polymer drug carrier ; micelles Subject RIV CD - Macromolecular Chemistry R&D Projects IAA400500806 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40500505 - UMCH-V (2005-2011) Annotation Novel amphiphilic HPMA copolymers designed as polymer carriers of anti-cancer drugs (e.g. doxorubicin) were synthesised. The copolymers formed supramolecular structures in aqueous environment and thus increase drug accumulation in solid tumours due to the EPR (enhanced permeability and retention) effect could be expected. In addition, copolymers contained biodegradable linkages between hydrophilic polymer chains and hydrophobic molecules in order to allow disassembling of the supramolecular structure after completing their drug carrier function and renal removal of copolymers from the body. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2008
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