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Steroid sulfatase and sulfuryl transferase activities in human brain tumors
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SYSNO ASEP 0306462 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Steroid sulfatase and sulfuryl transferase activities in human brain tumors Title Aktivity steroidních sulfatáz a sulfuryl transferáz v nádorech lidského mozku Author(s) Kříž, L. (CZ)
Bičíková, M. (CZ)
Mohapl, M. (CZ)
Hill, M. (CZ)
Černý, Ivan (UOCHB-X)
Hampl, R. (CZ)Source Title Journal of Steroid Biochemistry and Molecular Biology. - : Elsevier - ISSN 0960-0760
Roč. 109, č. 1 (2008), s. 31-39Number of pages 9 s. Language eng - English Country GB - United Kingdom Keywords dehydroepiandrosterone ; steroid sulfatase ; steroid sulfuryl transferase ; brain Subject RIV CC - Organic Chemistry CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000255301200005 DOI 10.1016/j.jsbmb.2007.12.004 Annotation Neuroactive steroids (dehydroepiandrosterone, pregnenolone) and their sulfates act as modulators of glutamate and gamma-aminobutyrate type A receptors in the brain The physiological ratio of these neuromodulators is maintained by two enzymes present in the brain, namely, steroid sulfatase (STS) and steroid sulfuryl transferase (SULT). Following previous determination of their activities in monkey brains, their activities were evaluated in human brain tumors. Radioimmunoassay and GC-MS were used for determination of products. Both enzyme activities were measured in the 55 most frequent human brain tumors (glioblastomas, pituitary adenomas, meningiomas, astrocytomas). Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2008
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