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Synthesis, cytostatic and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- and 6-[2-(dialkylamino)vinyl]purine nucleosides
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SYSNO ASEP 0305989 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis, cytostatic and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- and 6-[2-(dialkylamino)vinyl]purine nucleosides Title Syntéza, cytostatická a preotivirová aktivita nových 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- a 6-[2-(dialkylamino)vinyl]purinových nukleosidů Author(s) Kuchař, Martin (UOCHB-X)
Hocek, Michal (UOCHB-X) RID, ORCID
Pohl, Radek (UOCHB-X) RID, ORCID
Votruba, Ivan (UOCHB-X) RID
Shih, I. (US)
Mabery, E. (US)
Mackman, R. (US)Source Title Bioorganic & Medicinal Chemistry. - : Elsevier - ISSN 0968-0896
Roč. 16, č. 3 (2008), s. 1400-1424Number of pages 25 s. Language eng - English Country GB - United Kingdom Keywords purines ; nucleosides ; conjugate additions ; cytostatic activity Subject RIV CC - Organic Chemistry R&D Projects 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1QS400550501 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000253720100032 DOI https://doi.org/10.1016/j.bmc.2007.10.063 Annotation Novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]- and 6-[2-(dialkylamino)vinyl]purine nucleosides were prepared by conjugate additions of nucleophiles to vinyl or ethynylpurines. Cytostatic and antiviral activity of the title compounds is reported. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2008
Number of the records: 1