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Preparation, biological activity and endogenous occurrence of N-6-benzyladenosines
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SYSNO ASEP 0305966 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Preparation, biological activity and endogenous occurrence of N-6-benzyladenosines Překlad názvu Preparation, biological activity and endogenous occurrence of N-6-benzyladenosines Tvůrce(i) Doležal, Karel (UEB-Q) RID, ORCID
Popa, Igor (UEB-Q)
Hauserová, Eva (UEB-Q)
Spíchal, Lukáš (UEB-Q) RID, ORCID
Chakrabarty, K. (CH)
Novák, Ondřej (UEB-Q) RID, ORCID, SAI
Kryštof, Vladimír (UEB-Q) RID, ORCID
Voller, Jiří (UEB-Q) RID, ORCID
Holub, Jan (UEB-Q)
Strnad, Miroslav (UEB-Q) RID, ORCIDZdroj.dok. Bioorganic & Medicinal Chemistry. - : Elsevier - ISSN 0968-0896
Roč. 15, č. 11 (2007), s. 3737-3747Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova N-6-benzyladenosine ; cytokinin ; receptor Vědní obor RIV ED - Fyziologie CEP GA206/07/0570 GA ČR - Grantová agentura ČR GA522/06/0108 GA ČR - Grantová agentura ČR Další zdroj jiné veřejné zdrojejiné veřejné zdroje CEZ AV0Z50380511 - UEB-Q (2005-2011) DOI https://doi.org/10.1016/j.bmc.2007.03.038 Anotace Cytokinin activity of forty-eight 6-benzyladenosine derivatives at both the receptor and cellular levels as well as their anticancer properties were compared in various in vitro assays. The compounds were prepared by the condensation of 6-chloropurine riboside with corresponding substituted benzylamines and characterized by standard collection of physico-chemical methods. The majority of synthesized derivatives exhibited high activity in all three of the cytokinin bioassays used (tobacco callus, wheat leaf senescence and Amaranthus bioassay). The highest activities were observed in the senescence bioassay. For several of the compounds tested, significant differences in activity were found between the bioassays used, indicating that diverse recognition systems may operate. This suggests that it may be possible to modulate particular cytokinin-dependent processes with specific compounds. In contrast to their high activity in bioassays, the tested compounds were recognized with only very low sensitivity in both Arabidopsis thaliana AHK3 and AHK4 receptor assays. The prepared derivatives were also investigated for their antiproliferative properties on cancer and normal cell lines. Several of them showed very strong cytotoxic activity against various cancer cell lines. On the other hand, they were not cytotoxic for normal murine fibroblast (NIH/3T3) cell line. This anticancer activity of cytokinin ribosides may be important, given that several of them occur as endogenous compounds in different organisms. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2008
Number of the records: 1