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Sensitivity and specificity of the bioassay of estrogenicity in mammary gland and seminal vesicles of male mice
- 1.0213391 - UZFG-Y 20023002 RIV CZ eng J - Journal Article
Škarda, Josef
Sensitivity and specificity of the bioassay of estrogenicity in mammary gland and seminal vesicles of male mice.
Physiological Research. Roč. 51, č. 3 (2002), s. 267-276. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR GA523/99/0843; GA AV ČR KSK5020115
Keywords : bioassay * estrogenicity * mammary gland
Subject RIV: ED - Physiology
Impact factor: 0.984, year: 2002
The effects of a combination of estradiol plus progesterone in the mammary gland were mimicked by norethindrone acetate and inhibited by both testosterone and cortisol. Estradiol,progesterone, norethindrone acetate, or testosterone did not affect spleen weight and size of mammary lymph nodes.However, cortisol significantly decreased not only spleen weights but also size of mammary lymph nodes.The results show that simultaneous evaluation of mammary gland growth, seminal vesicles, and spleen weight in the same animal is suitable for bioassay of estrogenicity as well as for detection of androgenic and antiandrogenic activities.
Permanent Link: http://hdl.handle.net/11104/0108929
Number of the records: 1