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Combining combinatorial chemistry and affinity chromatography for systematically probing protein-ligand interactions: application to the development of highly selective inhibitors of human betaine: homocysteine .I.S./I.-methyltransferase
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SYSNO ASEP 0194859 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Combining combinatorial chemistry and affinity chromatography for systematically probing protein-ligand interactions: application to the development of highly selective inhibitors of human betaine: homocysteine .I.S./I.-methyltransferase Author(s) Collinsová, Michaela (UOCHB-X) RID
Castro, C. (US)
Garrow, T. A. (US)
Yiotakis, A. (GR)
Dive, V. (FR)
Jiráček, Jiří (UOCHB-X) RID, ORCIDSource Title Peptides 2002. Proceedings of the Twenty-Seventh European Peptide Symposium / Benedetti E. ; Pedone C.. - Napoli : Edizioni Ziino, 2002 - ISBN 88-900948-1-8 Pages s. 942-943 Number of pages 2 s. Action Peptides 2002. European Peptide Symposium /27./ Event date 31.08.2002-06.09.2002 VEvent location Sorrento Country IT - Italy Event type EUR Language eng - English Country IT - Italy Keywords BHMT ; inhibitor ; affinity chromatography Subject RIV CE - Biochemistry R&D Projects IAB4055003 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z4055905 - UOCHB-X Annotation The results reported in this study validate the concept that combining combinatorial chemistry to affinity chromatography makes possible to identify, without any .I.a priori./I. hypothesis, novel protein targets for phosphinic pseudopeptides. And .I.vice versa./I., selective inhibitors of BHMT were developed despite rather limited diversity of pseudopeptide library used to fish out the proteins. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2004
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