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Combining combinatorial chemistry and affinity chromatography for systematically probing protein-ligand interactions: application to the development of highly selective inhibitors of human betaine: homocysteine .I.S./I.-methyltransferase
- 1.0194859 - UOCHB-X 20030167 RIV IT eng C - Conference Paper (international conference)
Collinsová, Michaela - Castro, C. - Garrow, T. A. - Yiotakis, A. - Dive, V. - Jiráček, Jiří
Combining combinatorial chemistry and affinity chromatography for systematically probing protein-ligand interactions: application to the development of highly selective inhibitors of human betaine: homocysteine .I.S./I.-methyltransferase.
Peptides 2002. Proceedings of the Twenty-Seventh European Peptide Symposium. Napoli: Edizioni Ziino, 2002 - (Benedetti, E.; Pedone, C.), s. 942-943. ISBN 88-900948-1-8.
[Peptides 2002. European Peptide Symposium /27./. Sorrento (IT), 31.08.2002-06.09.2002]
R&D Projects: GA AV ČR IAB4055003
Institutional research plan: CEZ:AV0Z4055905
Keywords : BHMT * inhibitor * affinity chromatography
Subject RIV: CE - Biochemistry
The results reported in this study validate the concept that combining combinatorial chemistry to affinity chromatography makes possible to identify, without any .I.a priori./I. hypothesis, novel protein targets for phosphinic pseudopeptides. And .I.vice versa./I., selective inhibitors of BHMT were developed despite rather limited diversity of pseudopeptide library used to fish out the proteins.
Permanent Link: http://hdl.handle.net/11104/0090529
Number of the records: 1