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Multiple antigen glycopeptides (MAGs) with Tn tumour antigens and incorporated adjuvant: synthesis and immunobiological activities
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SYSNO ASEP 0194857 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Multiple antigen glycopeptides (MAGs) with Tn tumour antigens and incorporated adjuvant: synthesis and immunobiological activities Author(s) Ježek, Jan (UOCHB-X) RID
Kelkar, Shripad (UOCHB-X)
Vepřek, Pavel (UOCHB-X)
Hajdůch, M. (CZ)
Sejbal, J. (CZ)
Trnka, T. (CZ)Source Title Peptides 2002. Proceedings of the Twenty-Seventh European Peptide Symposium / Benedetti E. ; Pedone C.. - Napoli : Edizioni Ziino, 2002 - ISBN 88-900948-1-8 Pages s. 524-525 Number of pages 2 s. Action Peptides 2002. European Peptide Symposium /27./ Event date 31.08.2002-06.09.2002 VEvent location Sorrento Country IT - Italy Event type EUR Language eng - English Country IT - Italy Keywords Tn antigen ; multiple antigen glycopeptide ; synthetic vaccine Subject RIV CE - Biochemistry R&D Projects GA303/01/0690 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z4055905 - UOCHB-X Annotation Multiple antigen glycopeptides (MAGs) containing both tumor antigens of Tn type and incorporated adjuvant norMurNAc-L-Abu-D-iGln were prepared using Fmoc and Dde protection. The obtained MAGs[norMurNAc-L-Abu-D-iGln-L-Lys(X-Y-Y-c-Abu] 2 -Lys-Gly-amide (I,X=Ac, Y=serine Tn; II, X=Ac, Y=threonine Tn; III, X=stearoyl, Y=threonine Tn) are studied for ability to induce humoral immune response. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2004
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