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Synthesis of optically active .I.N./I..sup.6./sup.-alkyl derivatives of (R)-3-(adenin-9-yl)-2-hydroxypropanoic acid and related compounds
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SYSNO ASEP 0194803 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Synthesis of optically active .I.N./I.6-alkyl derivatives of (R)-3-(adenin-9-yl)-2-hydroxypropanoic acid and related compounds Author(s) Krečmerová, Marcela (UOCHB-X) RID, ORCID
Buděšínský, Miloš (UOCHB-X) RID, ORCID
Masojídková, Milena (UOCHB-X)
Holý, Antonín (UOCHB-X)Source Title Collection of Czechoslovak Chemical Communications. - : Ústav organické chemie a biochemie AV ČR, v. v. i. - ISSN 0010-0765
Roč. 68, č. 5 (2003), s. 931-950Number of pages 20 s. Language eng - English Country CZ - Czech Republic Keywords adenine ; purines ; antivirals Subject RIV CC - Organic Chemistry R&D Projects IBS4055109 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) OC D13.20 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z4055905 - UOCHB-X Annotation Reaction of 6-chloropurine and other nucleobases with (R)-oxiranecarboxylate was studied. Ethyl (R)-3-(6-chloropurin-9-yl)-2-hydroxypropanoate was hydrolyzed to corresponding acid and then treated with various amines to give a series of N 6 -substituted (R)-3-(adenin-9-yl)2-hydroxypropanoic acids. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2004
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