Kinetics of the dimerization of retroviral proteases: The

Name: Kinetics of the dimerization of retroviral proteases: The "fireman's grip" and dimerization
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Kinetics of the dimerization of retroviral proteases: The "fireman's grip" and dimerization

1.

SYSNO ASEP	0194775
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	Kinetics of the dimerization of retroviral proteases: The "fireman's grip" and dimerization
Author(s)	Ingr, Marek (UOCHB-X) Kondrová, Taťána (UOCHB-X)_{RID, ORCID} Stříšovský, Kvido (UOCHB-X)_{RID, ORCID} Majerová, E. (CZ) Konvalinka, Jan (UOCHB-X)_{RID, ORCID}
Source Title	Protein Science. - : Wiley - ISSN 0961-8368 Roč. 12, - (2003), s. 2173-2182
Number of pages	10 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	retroviral protease ; dimerization ; HIV protease
Subject RIV	CE - Biochemistry
R&D Projects	NI6339 GA MZd - Ministry of Health (MZ)
CEZ	AV0Z4055905 - UOCHB-X
Annotation	We prepared two pairs of the wild-type and mutant proteases from HIV and myeloblastosis-associated virus harboring either Ser or Thr in their Asp-Thr(Ser)-Gly triplet. The equilibrium dimerization constants differed by an order of magnitude within the relevant pairs. The dimer association contributes to this difference more than does the dissociation.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
Year of Publishing	2004

Number of the records: 1