Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates
1.
SYSNO ASEP
0194569
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates
Author(s)
Balzarini, J. (BE) Pannecouque, C. (BE) De Clercq, E. (BE) Aquaro, S. (IT) Perno, C. F. (IT) Egberink, H. (NL) Holý, Antonín (UOCHB-X)
Source Title
Antimicrobial Agents and Chemotherapy. - : American Society for Microbiology
- ISSN 0066-4804
Roč. 46, č. 7 (2002), s. 2185-2193
Number of pages
9 s.
Language
eng - English
Country
US - United States
Keywords
nucleoside phosphonates
Subject RIV
CC - Organic Chemistry
R&D Projects
GV203/96/K001 GA ČR - Czech Science Foundation (CSF)
CEZ
AV0Z4055905 - UOCHB-X
Annotation
Anovel class of acyclic nucleoside phosphonates has been discovered in which the base consists of a pyrimidine preferably containing an amino group at C-2 and C-4 and a 2-(phosphonomethoxy) ethoxy (PMEO) or a 2-(phosphonomethoxy)propoxy (PMPO) group at C-6. The 6-PMEO 2,4-diaminopyrimidine and 6-PMPO 2,4-diaminopyrimidine derivatives showed potent activity HIV.
