0194399 - UOCHB-X 20020065 RIV CZ eng C - Conference Paper (international conference)
Otmar, Miroslav - Masojídková, Milena - Votruba, Ivan - Holý, Antonín
Synthesis and cytostatic activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds.
80-86241-16-5. In: Chemistry of Nucleic Acid Components. Praha: UOCHB AV ČR, 2002 - (Točík, Z.; Hocek, M.), s. 38-39. Collection Symposium Series., 5.
[Chemistry of Nucleic Acid Components. Symposium /12./. Špindlerův Mlýn (CZ), 03.09.2002-08.09.2002]
R&D Projects: GA MŠMT OC D13.20
Institutional research plan: CEZ:AV0Z4055905
Keywords : cytostatic activity
Subject RIV: CC - Organic Chemistry

2,6-Diamino-9-benzyl-9-deazapurine and 9-benzyl-2,6-bis(benzylamino)-9-deazapurine were synthesized by reductive cyclization of the corresponding 6-cyanomethyl-5-nitropyrimidines. Both compounds exhibit cytostatic activity in human T-lymphoblastoid CCRF-CEM cells.
Permanent Link: http://hdl.handle.net/11104/0090076