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Interaction of Guanine Phosphonomethoxyalkyl Derivatives with GMP Kinase Isoenzymes
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SYSNO ASEP 0193831 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Interaction of Guanine Phosphonomethoxyalkyl Derivatives with GMP Kinase Isoenzymes Author(s) Krejčová, Romana (UOCHB-X)
Horská, Květoslava (UOCHB-X)
Votruba, Ivan (UOCHB-X) RID
Holý, Antonín (UOCHB-X)Source Title Biochemical Pharmacology. - : Elsevier - ISSN 0006-2952
Roč. 60, - (2000), s. 1907-1913Number of pages 7 s. Language eng - English Country US - United States Subject RIV CE - Biochemistry R&D Projects GV203/96/K001 GA ČR - Czech Science Foundation (CSF) NL5423 GA MZd - Ministry of Health (MZ) CEZ AV0Z4055905 - UOCHB-X Annotation Substrate activity and inhibitory potency of guanine and structurally related 2,6-diaminopurine phosphonomethoxyalkyl derivatives towards GMP kinase isoenzymes from L1210 cells was studied. Kinetic data have shown that (R)-PMPG was a good substrate. The inhibitory activities of the individual compounds on GMP kinase isoenzymes decreased in the following order: (S)-HPMPG>(R)-PMPG>PMEG>(R)-HPMPG>(S)-PMPG>PMEDAP=(R)-PMPDAP=(S)-PMPDAP. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2001
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