Studying the influence of prolyl amide geometry on bioactivity with 5-.I.t./I.-butylproline oxytocin analogs
1.
SYSNO ASEP
0193808
Document Type
C - Proceedings Paper (int. conf.)
R&D Document Type
Conference Paper
Title
Studying the influence of prolyl amide geometry on bioactivity with 5-.I.t./I.-butylproline oxytocin analogs
Author(s)
Bélec, L. (CA) Slaninová, Jiřina (UOCHB-X) Lubell, W. D. (CA)
Source Title
Proceedings of the 16th American Peptide Symposium. Peptides for the New Millennium / Fields G. B. ; Tam J. P. ; Barany G.. - Boston : Kluwer, 2000
- ISBN 0-7923-6445-7
Pages
s. 630-631
Number of pages
2 s.
Action
Peptides for the New Millennium. American Peptide Symposium /16./
Event date
26.06.1999-01.07.1999
VEvent location
Minneapolis
Country
US - United States
Language
eng - English
Country
US - United States
Subject RIV
CE - Biochemistry
R&D Projects
KSK2055603 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ
AV0Z4055905 - UOCHB-X
Annotation
Three OT analogs were synthesized in which (2S, 5R)-5-tbutylproline was substituted for proline in OT, [Mpa1]-OT (potent agonist) and [dPen1]-OT (potent antagonist). The new analogues were studied using NMR spectroscopy and their biological potency was determined the prolyl amide geometry was correlated with the biological activity.
