Synthesis of acyclic adenine 8,N-anhydronucleosides
1.
SYSNO ASEP
0193802
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
Synthesis of acyclic adenine 8,N-anhydronucleosides
Author(s)
Meszárosová, Kateřina (UOCHB-X) Holý, Antonín (UOCHB-X) Masojídková, Milena (UOCHB-X)
Source Title
Collection of Czechoslovak Chemical Communications. - : Ústav organické chemie a biochemie AV ČR, v. v. i.
- ISSN 0010-0765
Roč. 65, č. 7 (2000), s. 1109-1125
Number of pages
17 s.
Language
eng - English
Country
CZ - Czech Republic
Subject RIV
CC - Organic Chemistry
R&D Projects
GV203/96/K001 GA ČR - Czech Science Foundation (CSF)
CEZ
AV0Z4055905 - UOCHB-X
Annotation
9-(4-Hydroxybutyl)-8-bromoadenine was prepared by bromination of 9-(4-hydroxybutyl)adenine. Treatment with thionyl chloride gave 9-(4-chlorobutyl)-8-chloroadenine which was transformed to 6-alkyl-6,7,8,9-tetrahydro-10H-[1,3]diazepino[1,2-e]purine-4-amines or to 6,7,8,9-tetrahydro-10H-[1,3]diazepino[1,2-e]purine-4-amine by reaction with cyclopropylamine, propylamine or ammonia.
