The Effect of pyroglutamic fragments of vasopressin and oxytocin on the retention of memory after intoxication by neurotoxins QB and DSP-4 in rats
1.
SYSNO ASEP
0193679
Document Type
C - Proceedings Paper (int. conf.)
R&D Document Type
Conference Paper
Title
The Effect of pyroglutamic fragments of vasopressin and oxytocin on the retention of memory after intoxication by neurotoxins QB and DSP-4 in rats
Author(s)
Koupilová, M. (CZ) Patočka, J. (CZ) Barth, Tomislav (UOCHB-X)
ISBN
80-86241-06-8
Source Title
Biologically Active Peptides / Slaninová J. ; Barth T.. - Praha : ÚOCHB AVČR, 1999
Pages
s. 34-36
Number of pages
3 s.
Action
Biologically Active Peptides. Conference /6./
Event date
21.04.1999-23.04.1999
VEvent location
Praha
Country
CZ - Czech Republic
Language
eng - English
Country
CZ - Czech Republic
Keywords
T-maze ; Y-maze
Subject RIV
CE - Biochemistry
R&D Projects
GA306/95/0268 GA ČR - Czech Science Foundation (CSF)
CEZ
AV0Z4055905 - UOCHB-X
Annotation
Effects of six analogs of AVP fragment 4-9 on cognitive impairment induced by cholinotoxin 3-quinuclidine benzilate (QB) or by noradrenotoxin (DSP-4) were investigated by means of Y-maze with aversive stimulation and T-maze with appetitive stimulation in Wistar rats. QB and DSP-4 induced a severe learning deficit in pretrained animals. Single preventive administration of the peptides reversed the QB and DSP-4 induced impairment of the retention of memory.
