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Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase Csk and is involved in regulation of T cell activation
- 1.0191077 - UMG-J 20000180 RIV US eng J - Journal Article
Brdička, Tomáš - Pavlištová, Dagmar - Leo, A. - Bruyns, E. - Kořínek, Vladimír - Angelisová, Pavla - Scherer, J. - Shevchenko, A. - Shevchenko, A. Jr. - Hilgert, Ivan - Černý, Jan - Drbal, Karel - Kuramitsu, Y. - Kornacker, B. - Hořejší, Václav - Schraven, B.
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase Csk and is involved in regulation of T cell activation.
Journal of Experimental Medicine. Roč. 191, č. 9 (2000), s. 1591-1604. ISSN 0022-1007. E-ISSN 1540-9538
R&D Projects: GA ČR GA204/99/0367
Institutional research plan: CEZ:AV0Z5052915
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 15.236, year: 2000
A cDNA was cloned which encodes a novel transmembrane adapter protein PAG. This molecule functions as an adapter mediating association of a key enzyme Csk regulating the activity of Src-family kinases. PAG may be of key importance in regulation of cell growth and immunoreceptor signaling.
Permanent Link: http://hdl.handle.net/11104/0086837
Number of the records: 1