Comparative Measurements of Total Body Water in Healthy Volunteers by On-line Breath Deuterium Measurement and other Near-subject Methods

Smith, D.; Engel, B.; Diskin, A. M.; Španěl, Patrik; Davies, S. J.

Number of the records: 1

Comparative Measurements of Total Body Water in Healthy Volunteers by On-line Breath Deuterium Measurement and other Near-subject Methods

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SYSNO ASEP	0181625
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	Comparative Measurements of Total Body Water in Healthy Volunteers by On-line Breath Deuterium Measurement and other Near-subject Methods
Author(s)	Smith, D. (GB) Engel, B. (GB) Diskin, A. M. (GB) Španěl, Patrik (UFCH-W)_{RID, ORCID} Davies, S. J. (GB)
Source Title	American Journal of Clinical Nutrition - ISSN 0002-9165 Roč. 76, - (2002), s. 1295-1301
Number of pages	7 s.
Language	eng - English
Country	US - United States
Keywords	measurements ; bioimpedance analysis
Subject RIV	CF - Physical ; Theoretical Chemistry
R&D Projects	GA203/00/0632 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z4040901 - UFCH-W
Annotation	Background: Accurate and rapid determination of total body water (TBW), a fundamental component of body composition, is a desirable goal in the study of physiology and the management of many medical conditions. We have developed a new breath test, using Flowing-afterglow mass spectrometry (FA-MS) and deuterium dilution, which enables the immediate determination of TBW from single exhalations. Objective: To demonstrate the efficacy of the new FA-MS method in determining TBW in healthy subjects, and compare the results obtained with those from multifrequency bioimpedance analysis (BIA) and published regression equations. Design: Following baseline measurement of breath deuterium abundance (FA-MS), 24 healthy subjects took 0.3g/kg body weight D2O. A second breath sample was taken after two hours to measure the increase in deuterium and thus calculate TBW. BIA was carried out using a Xitron Hydra (4200). Methods were compared using Pearson correlation and Bland-Altman analyses.
Workplace	J. Heyrovsky Institute of Physical Chemistry
Contact	Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
Year of Publishing	2004

Number of the records: 1