Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine against Schistosomiasis mansoni in mice
1.
SYSNO ASEP
0173812
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine against Schistosomiasis mansoni in mice
Author(s)
Botros, S. (GE) William, S. (GE) Hammam, O. (GE) Zídek, Zdeněk (UEM-P) Holý, Antonín (UOCHB-X)
Source Title
Antimicrobial Agents and Chemotherapy. - : American Society for Microbiology
- ISSN 0066-4804
Roč. 47, č. 12 (2003), s. 3853-3858
Number of pages
6 s.
Language
eng - English
Country
US - United States
Keywords
schistosoma mansoni
Subject RIV
FH - Neurology
R&D Projects
GA305/00/0048 GA ČR - Czech Science Foundation (CSF)
GA305/03/1470 GA ČR - Czech Science Foundation (CSF)
CEZ
AV0Z5008914 - FKU-U, UEM-P
AV0Z5039906 - UEM-P
Annotation
Administration of one of the acyclic nucleoside phosphonates, HPMPA, to mice infected with Schistosoma mansoni resulted in suppression of total numbers of female and coupled worms, complete disappearance of immature and mature ggs, with 99-100% of the eggs being dead. Greatly reduced or no hepatic egg-induced granulomas were present in treated mice.
