0173812 - UEM-P 20033138 RIV US eng J - Journal Article
Botros, S. - William, S. - Hammam, O. - Zídek, Zdeněk - Holý, Antonín
Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine against Schistosomiasis mansoni in mice.
Antimicrobial Agents and Chemotherapy. Roč. 47, č. 12 (2003), s. 3853-3858. ISSN 0066-4804. E-ISSN 1098-6596
R&D Projects: GA ČR GA305/00/0048; GA ČR GA305/03/1470
Institutional research plan: CEZ:AV0Z5008914; CEZ:AV0Z5039906
Keywords : schistosoma mansoni
Subject RIV: FH - Neurology
Impact factor: 4.246, year: 2003

Administration of one of the acyclic nucleoside phosphonates, HPMPA, to mice infected with Schistosoma mansoni resulted in suppression of total numbers of female and coupled worms, complete disappearance of immature and mature ggs, with 99-100% of the eggs being dead. Greatly reduced or no hepatic egg-induced granulomas were present in treated mice.
Permanent Link: http://hdl.handle.net/11104/0070838